Skip to main content
. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Chem Commun (Camb). 2012 May 9;48(47):5838–5840. doi: 10.1039/c2cc31973j

Table 2.

Rhodium-catalyzed O—H insertion

graphic file with name nihms376594u2.jpg
entry R product time (h) C-4:C-6a yield (%)b
1 -CH2CH3 5a 6 >95:5 61
2 -CH3 5b 6 76:24 49
3 -CH2Ph 5c 12 >95:5 52
4 -(CO)CH3 5d 8 92:8 68
5 -(CO)CH2CH3 5e 6 88:12 55
6 -(CO)CH2Ph 5f 16 >95:5 41
a

Ratio determined by 1H NMR spectroscopy of the crude reaction mixture. All reactions were run at a concentration of 0.15 M with respect to 2.

b

Isolated yield of the C-4 regioisomer