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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Chem Commun (Camb). 2012 May 9;48(47):5838–5840. doi: 10.1039/c2cc31973j

Table 3.

Rhodium-catalyzed O—H insertion of 4

graphic file with name nihms376594u3.jpg
entry R product time (h) C-4:C-6a yield (%)b
1 -CH2CH3 6a 8 90:10 53
2 -CH3 6b 10 93:7 44
3 -CH2Ph 6c 10 >95:5 45
a

Ratio determined by 1H NMR spectroscopy of the crude reaction mixture. All reactions were run at a concentration of 0.15 M with respect to 2.

b

Isolated yield of the C-4 regioisomer