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. 2012 Apr 3;27(6):1829–1839. doi: 10.1093/humrep/des101

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© The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ROC curve analysis showing the predictive value of serum AMH at the start of the stimulation for the need for a gonadotrophin-dose increase (A) or decrease (B) on stimulation day 6 in patients treated with HP-hMG or rFSH in the long GnRH agonist protocol. All patients had received starting doses of 225 IU/day for the first 5 days. The diagonal line is the reference line of no discrimination (AUC = 0.5). Cut-off values for increased dose were 23.0 pmol/l for HP-hMG (sens. 67.8%, spec. 67.1%) and 21.4 pmol/l for rFSH (sens. 74.6%, spec. 73.6%). The cut-off values for decreased dose were 32.4 pmol/l for HP-hMG (sens. 70.8%, spec. 72.6%) and 37.4 pmol/l for rFSH (sens. 75.0%, spec. 80.7%).