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. 2012 May 14;61(6):1372–1380. doi: 10.2337/db11-1355

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Associations of genetic variants regulating metabolite levels with HOMA-IR (A) and the strongest circulating metabolite measure (B). Associations for rs1260326 in GCKR with the metabolites before (C) and after (D) adjustment for triglycerides. Error bars indicate 95% CIs and numbers indicate P values of association. All associations were adjusted for sex, age, waist, and population structure and meta-analyzed for the two cohorts (n = 6,343). Association magnitudes are in units of 1 SD HOMA-IR or metabolite concentration per allele copy. Av., average.