FIG. 1.

Effects of TCDC on glucose-induced insulin secretion from mouse islets. A: Insulin release was measured in steady-state incubations (60 min). n is given within each bar. B: Islets were perifused with 3 mmol/L glucose for 10 min. White bars: Glucose-induced insulin release. Black and hatched bars: Insulin secretion in the presence of TCDC (glucose and TCDC concentrations as indicated). Thereafter, glucose was increased to 15 mmol/L. TCDC was added after 30-min glucose stimulation. C: Representative experiment with perifused islets. *P ≤ 0.05, ***P ≤ 0.001.