FIG. 7.
Insulin secretion from islets of SUR1-KO mice and tolbutamide (tolb.)-treated WT islets. A: TCDC and GW4064 did not augment glucose-induced secretion in islets from SUR1-KO mice. Islets were incubated in the presence of 15 mmol/L glucose (G15), with G15 + TCDC (black bar) or G15 + GW4064 (hatched bar). B: TCDC was without effect on insulin release in WT islets in the presence of the KATP channel blocker tolbutamide. n is given within each bar. Islets were incubated in the presence of 15 mmol/L glucose, the indicated concentration of tolbutamide (control, white bars) and tolbutamide + TCDC (black bars).