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. 2012 May 14;61(6):1434–1443. doi: 10.2337/db11-0499

FIG. 8.

FIG. 8.

JAK2/STAT3 signaling is required for the insulin resistance induced by Aβ. A: Knockdown of STAT3 by siRNA enhanced insulin-stimulated phosphorylation of InsR and Akt under insulin-resistant conditions induced by Aβ. B: Quantification of phosphorylated InsR and Akt levels shown in A. C: Inhibition of JAK2 by AG490 enhanced insulin-stimulated phosphorylation of InsR and Akt under insulin-resistant conditions induced by Aβ. D: Quantification of phosphorylated InsR and Akt levels shown in C. E: Knockdown of JAK2 by siRNA enhanced insulin-stimulated phosphorylation of InsR and Akt under insulin-resistant conditions induced by Aβ. F: Quantification of phosphorylated InsR and Akt levels shown in E. All the protein levels were normalized to tubulin. Data are presented as mean and SEM. *P < 0.05. NS, no significant difference.