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. 2012 May 14;61(6):1315–1322. doi: 10.2337/db11-1300

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — The frequency and trends of favorable longevity genotypes with aging. These data were obtained in ∼700 unrelated subjects from the longevity genes project at Albert Einstein College of Medicine, of which ∼350 were over the age of 95 years. Because in the U.S. approximately half of the population die by the time they reach age ∼80 years, subjects are selected for exceptional longevity. A polymorphism for longevity will be rather rare in individuals ∼60 years old but will be monotonically increased and overrepresented in centenarians. AdipoQ-del/del, homozygous deletion in the 3′-untranslated region adiponectin gene; Apo C3-CC, apolipoprotein C-3 genotype; CETP-VV, homozygosity genotype in CETP; FOXO3a-T, polymorphisms in the FOXO3A gene; IGFr, polymorphisms in the IGF-1 receptor gene; TSHr-G, polymorphisms in the TSH receptor gene (see text for references). Adapted from Barzilai et al. (74).