Figure 2. FBS0701 interferes with artemisinin but not the quinolines like chloroquine or quinine.

Fractional inhibition curve for the quinolines and artemisinin with FBS0701. Up to 10 uM FBS0701 does not change the low nM IC50 of artemisinin (filled square). In contrast for the quinolines 1, 5, 7.5 and 10 uM FBS0701 reduced the IC50 in an additive manner for chloroquine (empty circle), quinine (empty triangle) or quinidine (filled triangle). For each axis the concentration of drug in combination which equals the inhibition concentration 50% was divided by IC50 of drug alone.