Figure 3. Network analysis of the “insulin regulation and diabetes” pathway.

Members of this enriched module were linked together based on verified gene product interactions. Several distinct motifs were identified (shown in different colors). As expected, insulin assumed a central position in this network. One upregulated candidate, MLX (red), was the putative target of multiple downregulated miRNAs (blue) and is postulated to be a critical controller of visceral adipocytes' metabolic response to SF. Note that several other downregulated miRNAs interacted with members of this network, but are not shown in order to improve clarity.