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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Cell Physiol. 2012 Oct;227(10):3355–3362. doi: 10.1002/jcp.24071

Figure 3. Effect of LOX on MK biology and progression of BM fibrosis.

Figure 3

Extracellular LOX stimulates PDGF-mediated Erk and Akt signaling, contributing to MK progenitor proliferation. Inhibition of LOX by BAPN eliminates this effect. BAPN also inhibits collagen cross-linking through inhibition of the catalytic activity of LOX, hampering progression of myelofibrosis.