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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Immunol Rev. 2011 Nov;244(1):29–43. doi: 10.1111/j.1600-065X.2011.01060.x

Fig. 4. Combinatorial control of kinases facilitates stimulus specificity.

Fig. 4

Engagement of TNFRSFs activates pathways leading to the activation of ERK, JNK, p38, IKK2, and IKK1. Phosphorylation of downstream effectors induces a transcriptional program. Some genes require a synergistic function of several transcription factors and may thus be transcribed in a stimulus-specific manner. Specificity can also be achieved post-transcriptionally through p38-dependent regulation of mRNA stability.