Fig. 3.

Impaired motor coordination and skill learning on the rotarod is exacerbated in B6D2F1 transgenic mice. Latency to fall from the rotarod was recorded and, in all cases, transgenic mice were impaired relative to wild-type littermates in both genetic backgrounds and on both days of testing (P < 0.001). In addition, all genotypes and lines showed significant improvement in rotarod performance between days 1 and 2 (P < 0.001). Overall, B6D2F1 mice were impaired relative to B6 mice through the experiment irrespective of genotype (P ≤ 0.002)