Fig. 5.

Sensorimotor gating. a Acoustic startle response measurements. Both transgenic and wild-type B6D2F1 mice show reduced startle phenotypes relative to B6 mice. b Percent PPI of wild-type and transgenic mice at each prepulse. Average PPI was normal in mice in both genetic backgrounds at 8 weeks of age but decreased inhibition was observed by 10 weeks. Overall, B6D2F1 mice show increased inhibition compared to B6 mice. In (a) **Reflects a difference in performance between different genetic backgrounds (P < 0.001)