Figure 4.

Affected sib pairs. A: The simulation process. Three affected sib pairs were simulated to each have inherited two copies of a recent founder mutation allele. B: Pedigree input to HRRA. This includes the sibling data on the three pairs who carry the simulated mutation region and 27 other sib pairs who do not carry the mutation region. C: HRRA result on a representative simulation. For this case the P-value for the simulated region ranked at the 50th percentile among all simulations. [Color figures can be viewed in the online issue, which is available at http://www.wiley.com/humanmutation.]