Table 2.

Symptoms Described by Ms A

Event	Dates	Patient Described Symptoms
Discontinuation (on sick leave)	September 27, 2008–October 2, 2008	Loud buzzing noise in head and feeling dizzy, exhaustion, no sleep (lying awake as if taking amphetamines), crying/sobbing, short tempered, nausea and diarrhea, sensation of shaking all over inside, sensations of an evil being/evil presence in the room (incubus) when half asleep in bed, vivid disturbing nightmares, intermittent tinnitus (ringing)
	October 3, 2008–November 18, 2008
Returned to work	November 19, 2008–December 23, 2008	Constantly felt about to cry and often did, gradual tapering of the buzzing at the back of the head, waking in early hours, low energy, tinnitus (ringing) more persistent
Week of Christmas and New Year's day	December 24, 2008–January 3, 2009	Vomiting, free-floating anxiety, panic, nausea, feeling of high blood pressure in the head, insomnia, difficulty getting to sleep, waking in the early hours, self-loathing, low energy, constantly felt about to cry and often did, palpitations, shame, felt hopeless (but not actively suicidal), unable to enjoy anything/feel pleasure, loss of appetite, exhaustion, continuous tinnitus
Recommenced 75 mg venlafaxine	January 4, 2009–January 13, 2009	Edge taken off panic surges, continued nausea and loss of appetite (and consequent weight loss), difficulty getting to sleep and staying asleep throughout the night, constantly felt about to cry and often did, felt bad about self, exhaustion, continuous tinnitus
Increased to 150 mg venlafaxine	January 14, 2009–January 29, 2009	Gradual recovery, tinnitus continued with constant buzzing in head and intermittent ringing (mainly in or worse in right ear)
Continued on 150 mg venlafaxine	January 30, 2009 onward	Functional and well, tinnitus continued with unremitting buzzing in head and intermittent ringing (mainly in or worse in right ear)