Table 2.
Additives to UW solution to protect liver against ischemia/reperfusion. Nitric oxide, NO; platelet-activating factor, PAF; sinusoidal endothelial cells, SEC.
| Additives to UW solution | |||
|---|---|---|---|
| Liver transplantation | |||
| Drug | Specie | Ischemic time | Effect |
| Ruthenium red (mitochondrial Ca2+ uniporter inhibitor) | Rat | 24 h | ↓ Mitocondrial dysfunction |
| OP-4183 (PGI2 analogue) | Rat | 24 h | ↓ Oxidative stress |
| SAM (ATP precursor) | Rat | 24 h | ↓ Oxidative stress |
| Trifluoperazine (calmodulin inhibitor) | Dog | 24 h | ↓ Microcirculatory dysturbances |
| Sodium nitroprusside (NO donor) | Rat | 24, 48 h | ↓ Microcirculatory dysturbances |
| E5880 (PAF antagonist) | Pig | 8 h | ↓ Microcirculatory dysturbances |
| FR167653 (p38 inhibitor) | Rat | 30 h | ↓ Microcirculatory dysturbances |
| EGF, IGF-1, NGF-α | Pig | 18 h | ↑ ATP |
| LY294002 (PI3K inhibitor) | Rat | 3, 7, 9, 24 h | ↓ Apoptosis |
| IDN-1965 (caspase inhibitors) | Rat | 24, 30 h | ↓ Apoptosis |
| 8br-cAMP and 8br-cGMP (nucleotide analogs) | Rat | 24 h | ↓ NFα and neutrophil accumulation, |
| GSNO (NO donor) | Rat | 48 h | ↓ SEC damage |
| Pifithrin-alpha (p53 inhibitor) | Rat | 24, 48 h | ↓ Apoptosis |
| OP-4183 (PGI2 analogue) | Rat | 24 h | ↓ Oxidative stress |
| Tauroursodeoxy-cholate | Rat | 2 h | ↓ Endoplasmic reticulum stress |