Skip to main content
. 2012 Jun 15;139(12):2234–2245. doi: 10.1242/dev.075184

Fig. 8.

Fig. 8.

Canonical Wnt signaling functions upstream of ceh-12 in unc-4 mutant VA motor neurons. (A) pry-1(mu38) enhances the Unc-4 backward movement phenotype of unc-4(e2322ts) at 16°C. *P<0.05. n≥50. (B) The GSK-3β inhibitor LiCl induces a backward movement defect in WT animals that is partially rescued by ceh-12(gk391). *P<0.05. n≥150. (C) Constitutive activation of BAR-1 in WT A-class motor neurons with Punc-4::ΔNT-BAR-1 results in Unc-4-like movement. *P<0.05. n≥50. (D) ceh-12::GFP is ectopically expressed in VAs when BAR-1 is constitutively activated in a wild-type background. ***P<0.001 versus WT. n≥20 for each neuron. (E) UNC-4 antagonizes a canonical Wnt signaling pathway to preserve VA-type inputs.