Table 3.
Between-Group Comparisons for Angry or Happy vs. Neutral Faces at Baseline or Follow-up.
| Talairach Coordinates for peak values | Area | BA | Volume (mm3) | t value for peak values | |
|---|---|---|---|---|---|
| BASELINE | |||||
| Angry vs. Neutral | |||||
| Risperidone Group > HC | none | none | none | none | none |
| HC> Risperidone Group | 45 20 -3 | R inferior frontal gyrus | 47 | 108 | 5.10 |
| -0 16 -12 | L subgenual ACC | 25 | 108 | 4.65 | |
| -37 17 5 | L insula | 13 | 162 | 6.24 | |
| -49 -67 8 | L middle temporal gyrus | 19 | 297 | 4.91 | |
| Divalproex Group > HC | none | none | none | none | none |
| HC> Divalproex Group | 47 17 2 | R inferior frontal gyrus | 47/45 | 135 | 5.77 |
| 20 14 -1 | R putamen | 486 | 5.34 | ||
| -19 5 -1 | L putamen | 108 | 4.91 | ||
| 8 5 -13 | R subgenual ACC | 25 | 108 | 6.13 | |
| Risperidone Group > Divalproex Group | none | none | none | none | none |
| Divalproex Group> Risperidone Group | none | none | none | none | none |
| Happy vs. Neutral | |||||
| Risperidone Group > HC | none | none | none | none | none |
| HC> Risperidone Group | none | none | none | none | none |
| Divalproex Group > HC | none | none | none | none | none |
| HC> Divalproex Group | none | none | none | none | none |
| Risperidone Group > Divalproex Group | none | none | none | none | none |
| Divalproex Group > Risperidone Group | none | none | none | none | none |
| FOLLOW-UP | |||||
| Angry vs. Neutral | |||||
| Risperidone Group > HC | 56 -46 -19 | R inferior temporal gyrus | 37 | 108 | 4.10 |
| -6 8 -14 | L subgenual ACC | 25 | 108 | 3.99 | |
| -11 16 6 | L caudate | 108 | 2.74 | ||
| HC> Risperidone Group | none | none | none | none | none |
| Divalproex Group > HC | -36 35 -14 | L VLPFC | 47/11 | 108 | 2.15 |
| 37 50 -1 | R VLPFC | 45/46 | 270 | 3.05 | |
| 20 41 29 | R middle frontal gyrus | 9 | 108 | 3.71 | |
| 65 -31 -7 | R middle temporal gyrus | 21 | 189 | 3.44 | |
| HC> Divalproex Group | none | none | none | none | none |
| Risperidone Group > Divalproex Group | -2 -3 -8 | L subgenual ACC | 25 | 108 | 2.98 |
| -22 -5 -3 | L ventral striatum | 108 | 3.34 | ||
| Divalproex Group> Risperidone Group | -40 32 -7 | L inferior frontal gyrus | 47/11 | 108 | 2.82 |
| 63 -34 -7 | R middle temporal gyrus | 21 | 189 | 2.93 | |
| Happy vs. Neutral | |||||
| Risperidone Group > HC | 44 26 -13 | R inferior frontal gyrus | 47 | 216 | 4.77 |
| -49 -19 2 | L superior temporal gyrus | 22 | 297 | 5.21 | |
| HC> Risperidone Group | none | none | none | none | none |
| Divalproex Group > HC | none | none | none | none | none |
| HC> Divalproex Group | none | none | none | none | none |
| Risperidone Group > Divalproex Group | -25 -88 5 | L middle occipital gyrus | 18 | 324 | 4.36 |
| Divalproex Group> Risperidone Group | 62 -40 -4 | R middle temporal gyrus | 21 | 108 | 4.17 |
Note: Talairach coordinates and t values for clusters for which there is a significant three-way interaction (corrected p<0.05, with cluster contiguity threshold) in the whole-brain Analysis of Variance (ANOVA). ACC= anterior cingulate cortex; BA = Brodmann Area; HC=healthy control; L=left; R=right; VLPFC=ventrolateral prefrontal cortex.