Table 1.
Patients' characteristics and [18F]FDG-PET/CT findings.
| Patient no. | [18F]FDG-PET/CT scan no. | Age (years)/sex | Time from initial surgery to PET/CT (months) | TNM initial staging | Type of MTC | Calcitonin-CEA (pg/mL-ng/mL) | [18F]FDG-PET/CT findings (SUVmax) | [18F]FDG- PET/CT classification |
Biopsy-surgical excision |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A | 32/F | 192 | T1N1aM0 | MENIIA | 688–21.16 | — | FN | — |
| B | 216 | 821-NA | — | FN | — | ||||
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| 2 | 57/F | 216 | T2N1aM0 | Fam | 21000-NA | Neck (3), mediastinum (2.8), abdominal (3) | TP | — | |
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| 3 | A | 44/F | 21 | T4aNIbMo | S | 809–17.4 | — | FN | — |
| B | 30 | 1601-NA | Thyroid bed (2) | TP | — | ||||
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| 4 | 71/M | 83 | T3N1bM0 | S | 3604–54.2 | Neck (2.7) | TP | — | |
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| 5 | A | 63/F | 4 | T3N0M0 | S | 205–7.2 | — | FN | — |
| B | 13 | 352-NA | Liver (4.7) | TP | — | ||||
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| 6 | A | 49/M | 156 | T2N1aM0 | MENIIA | 1001–39.8 | — | FN | — |
| B | 164 | 1203-NA | — | FN | — | ||||
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| 7 | 39/F | 24 | T3N1bM0 | S | 77–0.63 | — | FN | Ex = (−) for MTC | |
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| 8 | 43/F | 11 | T1N1aM0 | S | 52.2–3.4 | — | FN | — | |
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| 9 | 40/M | 84 | T2N1bM0 | S | 2259–22.7 | Neck (4) | TP | Ex = (+) for MTC | |
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| 10 | A | 63/M | 240 | T3N0M0 | S | 705-NA | Neck (2.5) | TP | — |
| B | 252 | 860-NA | Neck (3.7) | TP | Ex = (+) for MTC | ||||
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| 11 | 21/F | 60 | T3N1bM0 | S | 1470-NA | Neck (2.1), mediastinum (2.2) | TP | — | |
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| 12 | A | 40/M | 48 | T3N1bM0 | Fam | 3601–1.3 | Thyroid bed (3.9), mediastinum (3.7) | TP | Ex = (+) for MTC |
| B | 63 | 6000-NA | Thyroid bed (4.6), mediastinum (4.2) | TP | Ex = (+) for MTC | ||||
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| 13 | 52/F | 36 | T3N1bM0 | S | 850–114.7 | — | FN | — | |
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| 14 | 49/F | 84 | T1N1bM0 | S | 936–84.4 | — | FN | — | |
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| 15 | 35/F | 216 | T1N0M0 | MENIIA | 79.1–2.1 | — | FN | — | |
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| 16 | 46/F | 120 | T3Ν1bM0 | MENIIA | 230–10.4 | — | FN | — | |
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| 17 | 56/F | 4 | T2N1bM0 | S | 63–12.4 | — | FN | — | |
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| 18 | 60/F | 48 | T1NIbMo | S | 98.8-NA | Mediastinum (2.5) | TP | — | |
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| 19 | 61/M | 36 | T1N1bM0 | S | 57–7 | — | FN | — | |
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| 20 | 68/F | 30 | T3N1aM0 | S | 145–7.1 | — | FN | — | |
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| 21 | 67/M | 120 | T3N0M0 | MENIIA | 200–11 | — | FN | — | |
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| 22 | 70/M | 36 | T1N1aM0 | MENIIA | 28.3–1.4 | — | FN | — | |
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| 23 | 55/F | 84 | T1N1aM0 | S | 95.1-NA | — | FN | — | |
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| 24 | 53/F | 108 | T3N1aM0 | Fam | 10704–72,9 | Neck (5.5) | TP | —— | |
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| 25 | 60/F | 9 | T2N0M0 | S | 35-NA | Neck (3) | FP | Ex = (−) for MTC | |
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| 26 | A | 47/F | 60 | T1N1bM0 | S | 883–34.5 | — | FN | — |
| B | 70 | 1360–40.2 | Thyroid bed (3.2), Neck (3.5) |
TP | Ex = (+) for MTC | ||||
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| 27 | 55/F | 72 | T1N0M0 | Fam | 100-NA | Neck (2.2) | TP | — | |
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| 28 | 28/F | 84 | T1N1bM0 | S | 622–13.4 | Neck (6.3) | TP | Ex = (+) for MTC | |
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| 29 | 66/F | 228 | T1N1bM0 | S | 17641-NA | Neck (2.5), mediastinum (4), Bones (5) |
TP | — | |
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| 30 | A | 73/M | 84 | T3N1bM0 | S | 450–130 | Mediastinum (4.3) | TP | Ex = (+) for MTC |
| B | 96 | 500-NA | Neck (7), mediastinum (3) | TP | — | ||||
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| 31 | 42/F | 72 | T1N0M0 | S | 33,4-NA | Neck (6.7) | FP | Ex = (−) for MTC | |
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| 32 | 72/M | 132 | T1N1bM0 | S | 36.6–4.1 | — | FN | — | |
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| 33 | 38/F | 132 | T1N1aM0 | Fam | 26.4–1 | Neck (4.4) | FP | Ex = (−) for MTC | |
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| 34 | 43/F | 204 | T1N0M0 | MENIIA | 26.2–2.2 | — | FN | — | |
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| 35 | 64/F | 84 | T4N1bM0 | S | 410–7.2 | Neck (3.9) | TP | — | |
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| 36 | 70/F | 456 | T1N0M0 | S | 295–1.2 | Neck (5) | TP | — | |
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| 37 | 40/M | 108 | T1N1aM0 | MENIIA | 2096–22.3 | Neck (5) | TP | Ex = (+) for MTC | |
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| 38 | 60/F | 180 | T1N0M0 | S | 330-NA | — | FN | — | |
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| 39 | 79/M | 8 | T1N0M0 | S | 137–5 | — | FN | — | |
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| 40 | 69/F | 48 | T3N0M0 | S | 453–10.2 | — | FN | — | |
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| 41 | 44/F | 300 | T1N0M0 | MENIIA | 5500-NA | Thyroid bed (3.5), Neck (2.6), Liver (5) |
TP | — | |
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| 42 | 62/M | 120 | T1N1bM0 | MENIIA | 101–1.9 | — | FN | — | |
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| 43 | 59/M | 21 | T1N0M0 | MENIIA | 4800–67 | Liver (6), mediastinum (2.9), bones (6.1) |
TP | — | |
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| 44 | 45/F | 7 | T3N1bM0 | S | 650-NA | Mediastinum (2.7) | TP | — | |
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| 45 | 29/F | 228 | T1N0M0 | S | 986-NA | — | FN | — | |
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| 46 | 42/F | 144 | T1N1bM0 | Fam | 893–34.9 | — | FN | — | |
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| 47 | 52/F | 8 | T2N0M0 | S | 291–1.2 | Neck (3.5) | TP | Ex = (+) for MTC | |
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| 48 | 12/M | 7 | T3N1aM0 | Fam | 92.4–4.5 | — | FN | — | |
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| 49 | 74/F | 120 | T1N0M0 | S | 48.6–4.6 | Neck (2.4) | TP | — | |
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| 50 | 65/F | 39 | T1N0M0 | S | 45-NA | — | FN | — | |
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| 51 | 79/F | 28 | T2N0M0 | S | 19.3–2.72 | — | FN | — | |
Ex: surgical excision; [18F]FDG-PET/CT: 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography; F: female; M: male; S: sporadic; Fam: familial; FN: false negative, TP: true positive; FP: false positive; MTC: medullary thyroid cancer; NA: not available.