Figure 3.
Transmission electron micrographs of dendrites in the IPL. (a–d) Ultrastructural images show the presence of double- or multiple-membrane autophagic vesicles (box) containing cell organelles in the dendrites of RGCs of a sham-operated control rat retina (a) and an experimental rat retina at 1 week (b), 2 weeks (c) and 4 weeks (d) after cauterization. (e) Comparison of the numbers of autophagic vesicles per transmission EM micrograph (50 μm2) in the cauterized rat retina. Three eyes used in each experimental period. Bar represents mean±S.D. *P<0.05 compared with the control. (f) In the retrobulbar portion of the optic nerve, where axon bundles of RGCs are located, no apparent increase of autophagic vesicles were observed. Representative image at 2 weeks after IOP elevation