Table 1. Growth inhibitory effects of various IAs on parental carcinoma cells and their MDR sublines.

		LD50 (nM)		Fold	Survival at 3000 nMa (%)
Drug	Cell line	Control	Illumination	Sensitization	Control	Illumination	Delta
C-1330	A549	5023±716	842±208	6	72±5	43±6	29
	A549/K1.5	12269±1119	850±23	14	87±4	28±1	59
C-1379	A549	6349±867	199±31	32	60±1	2±0.3	58
	A549/K1.5	15192±580	747±45	20	82±4	7±0.1	75
C-1375	A549	3054±260	212±29	14	50±3	3±2	47
	A549/K1.5	5264±877	541±56	10	70±5	3±0.6	67
	SW1573	5535±596	233±5	24	68±6	11±2	57
	SW1573/2R160	4384±125	330±56	13	74±3	24±4	50
	2008	3280±345	90±9	36	72±0.8	11±4	61
	2008/MRP1	5115±889	101±0.1	51	80±2	13±3	67

Abbreviations: IAs, imidazoacridinones; LD₅₀, 50% lethal dose; MDR, multidrug resistance

^aConcentration chosen with the highest delta of % survival between illuminated and nonilluminated cells