| PFLU_0088 |
kinB/algB |
|
Regulatory two-component system (2CS) region that is involved in alginate biosynthesis |
| PFLU_0979 |
algA |
GMP, PMI, manA
|
The two enzymatic activities of algA, GMP and PMI, are localized at the N- and C-terminals of the protein, respectively. GMP catalyzes the conversion of mannose-1-phosphage to GDP–mannose and PMI catalyzes the conversion of mannose-1-phosphate to GDP–mannose, which are required for the synthesis of alginate and the A-band of LPS |
| PFLU_0987 |
algK |
|
Alginate polymerization |
| PFLU_0988 |
alg44 |
|
Alginate polymerization |
| PFLU_0990 |
algD |
GMD GDP–mannose dehydrogenase |
The alginate biosynthetic operon is under the transcriptional control of the algD promoter. algD encodes GMD, which is required for A-band LPS synthesis and irreversible oxidation of GDP–D-mannose to GDP–D-mannuronic acid (activated precursor for alginate polymerization) |
| PFLU_1467 |
algU |
algT or sigma factor-22 (σ22) |
Positive regulator of alginate biosynthetic operon |
| PFLU_1468 |
mucA |
|
Negative regulator of alginate biosynthetic operon |
| PFLU_1469 |
mucB |
|
Negative regulator of alginate biosynthetic operon |
| PFLU_1471 |
mucD |
|
Negative regulator of alginate biosynthetic operon |
| PFLU_4443 |
FleQ |
|
Regulates flagellum biosynthesis and is negatively regulated by algU
|
| PFLU_4744 |
algZ |
|
Alginate polymerization |
| PFLU_5986 |
algC |
PMM, PGM, GMP |
Encodes the bifunctional enzyme PMM/PGM that is required for both alginate biosynthesis, and addition of glucose and or/rhamnose into the growing core of LPS (O-side chains of LPS) |
