Table 1.

Distribution of 3-week platelet and neutrophil-producing activities between the Lin⁻ALDH⁺ and Lin⁻ALDH⁻ cells in CB and mPB

End point	CB				mPB
	ALDH−		ALDH+		ALDH−		ALDH+
	Total	%	Total	%	Total	%	Total	%
Human platelets, (×103)/mL mouse PB*	51 ± 9	19 ± 5	290 ± 110	81 ± 5	60 ± 3	29 ± 13	260 ± 140	71 ± 13
Primitive CFU-Mks, > 50 Mks/colony†	270 ± 250	19 ± 12	450 ± 280	81 ± 12	3 ± 1	47 ± 15	9 ± 6	53 ± 15
Mature CFU-Mks, 3-49 Mks/colony†	1400 ± 220	53 ± 7	1400 ± 400	47 ± 7	150 ± 40	77 ± 13	50 ± 30	23 ± 13
Human neutrophils in mouse BM, %*	0.3 ± 0.3	12 ± 10	1.8 ± 0.9	88 ± 10	0.1 ± 0.02	5.4 ± 5	2.6 ± 1.1	95 ± 5
Primitive CFU-GMs, > 1000 cells/colony†	320 ± 50	7.6 ± 0.9	3900 ± 180	92 ± 1	100 ± 30	16 ± 10	840 ± 320	84 ± 10
Mature CFU-GMs, 20-1000 cells/colony†	550 ± 210	20 ± 1	2200 ± 770	80 ± 1	100 ± 20	11 ± 4	990 ± 260	89 ± 4

Data shown are the means ± SEM values derived from 3 experiments with 3 different preparations of CB or mPB. In vivo assays used 3-5 mice per group (ALDH⁺ and ALDH⁻ cells) in each experiment.

ALDH indicates aldehyde dehydrogenase; mPB, mobilized peripheral blood; Mk, megakaryocyte; and GM, granulocyte and macrophage.

^*Per 2.5 × 10⁴ Lin⁻ human cells.

^†Per 10⁵ Lin⁻ human cells.