Table 2.
End point | CB pool no. 1 |
CB pool no. 2 |
||||||
---|---|---|---|---|---|---|---|---|
CD38+ |
CD38− |
CD38+ |
CD38− |
|||||
Total | % | Total | % | Total | % | Total | % | |
Human platelets, (×103)/mL mouse PB* | 260 ± 100 | 41 | 370 ± 77 | 59 | 210 ± 100 | 37 | 360 ± 150 | 63 |
Primitive CFU-Mks, > 50 Mks/colony† | 6300 | 55 | 5200 | 45 | 550 | 58 | 400 | 42 |
Mature CFU-Mks, 3-49 Mks/colony† | 13 000 | 53 | 11 000 | 47 | 7300 | 53 | 6600 | 47 |
Human neutrophils in mouse BM, %* | ND | — | ND | — | 12 ± 8 | 85 | 2 ± 1 | 15 |
Primitive CFU-GMs, > 1000 cells/colony† | 26 000 | 55 | 21 000 | 45 | 9200 | 38 | 15 000 | 62 |
Mature CFU-GMs, 20-1000 cells/colony† | 23 000 | 56 | 18 000 | 44 | 9100 | 63 | 5400 | 37 |
In vivo data shown are the means ± SEM of results from 3 mice per group (Lin−ALDH+CD38+ and Lin−ALDH+CD38− cells) in each experiment.
ND indicates not detectable; and —, not applicable. See Table 1 for expansion of other abbreviations.
Per 2.5 × 104 Lin− human cells.
Per 105 Lin− human cells.