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. 2012 May 22;7(5):e37635. doi: 10.1371/journal.pone.0037635

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Munro et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Hierarchical clustering identified subsets of differentially expressed genes with similar expression profiles across groups. A cluster was chosen for further analysis (enlarged, cluster A); expression of genes in this cluster was relatively low in both sham-operated wild-type and EphA4 knockout samples and increased after injury in both genotypes. However the upregulation in injured EphA4 knockout samples was attenuated compared to injured wild-type samples. A number of genes with this expression profile were related to inflammation or immune function. KO = knockout.