Table 2.
Sequencing results of positive samples for mutation/SNPs screened for exon 5–8 of TP53 by HRM
| Sample no | Exon | Amino acid change | Coding description | Genomic description | Frequency of mutation/SNP | Cytogenetics |
|---|---|---|---|---|---|---|
| E355 | 6 | R213R | c.639A>G | g.12708A>G | (SNP- 0.023526) | Complex |
| rs1800372 | ||||||
| E597 | 7 | G244S | c.730G>A | g.13367G>A | 227 | Complex |
| E599 | 7 | G245S | c.733G>A | g.13370G> | 718 | Complex |
| E621 | 5 | R175G | c.523C>G | g.12511C>G | 1,092 | Complex |
| E624 | 7 | R249 K | c.746G>A | g.13383G>A | 573 | Complex |
| E626 | 8 | R273H | c.818G>A | g.13798G>A | 1,425 | ? |
| E627 | 6 | Y205C | c.614A>G | g.12683A>G | 158 | Query complex |
| E629 | 5 | P151A | c.451C>G | g.12439C>G | 210 | Normal |
| E639 | 5 | P151A | c.451C>G | g.12439C>G | 210 | Complex |
| E669 | 7 | R248E | c.743G>A | g.13380G>A | 1,544 | ? |
Frequency of mutation was collected from UMD P53 mutation database