Table 2.

List of the T-cell DE proteins with known HIV-1 protein interactions was obtained by comparing the DE proteins from our dataset with the two published HIV-human protein-protein interaction databases (HHPID at NCBI and Jäger’s database). Four DE proteins that were found in both databases are marked with an asterisk.

Cellular Protein	Gene Symbol	HIV protein	Log2 (FC)
4 hpi
actin, beta	ACTB	Tat	0.66
X-ray repair complementing defective repair in Chinese hamster cells 6	XRCC6	Tat, Vif	0.63
X-ray repair complementing defective repair in Chinese hamster cells 5	XRCC5	Tat	0.50
RAN binding protein 1*	RANBP1	Vpu, Rev	0.73
lactate dehydrogenase A	LDHA	Tat, Envelope gp 41	0.53
transferrin receptor (p90, CD71)	TFRC	Nef	0.53
moesin	MSN	Gag	0.50
adaptor-related protein complex 2, beta 1 subunit	AP2B1	Nef	−0.56
proteasome subunit, beta type, 6*	PSMB6	GP140, GP120, Tat	−0.76
karyopherin alpha 3 (importin alpha 4)	KPNA3	Matrix	−0.80
Vpr (HIV-1) binding protein*	VPRBP	Vpr	−1.10
protein phosphatase 2, regulatory subunit B	PPP2R2A	Vpr	−1.23
8 hpi
Importin 5	IPO5	Vpr	0.50
glucose-6-phosphate isomerase	GPI	gp 120	0.66
solute carrier family 3	SLC3A2	gp160	0.76
small nuclear ribonucleoprotein polypeptides B and B1	SNRPB	Tat	0.90
lysyl-tRNA synthetase*	KARS	Matrix, Gag, Capsid	−0.47
HIV-1 Tat specific factor 1	HTATSF1	Tat	−0.47
20 hpi
vinculin	VCL	Nef	0.50
caspase 3, apoptosis-related cysteine peptidase	CASP3	Vpr	−0.47
lymphocyte-specific protein tyrosine kinase	LCK	Nef	−0.47
transferrin receptor (p90, CD71)	TFRC	Nef	−1.06
sialophorin	SPN	gp 120	−1.73
eukaryotic translation initiation factor 4 gamma	EIF4G1	Retropepsin	−0.56