Table 1.
General characteristics of the total study sample and comparison between persons with and without incident late onset Alzheimer’s disease (LOAD)
| Variable | Total n = 1,459 |
No LOAD n = 1,314 |
LOAD n = 145 |
P value |
|---|---|---|---|---|
| Age in years, mean (SD) | 75.9 (6.5) | 75.5 (6.2) | 80.8 (7.1) | <0.0001 |
| Female sex, (%) | 1,001 (67.3) | 887 (67.5) | 97 (67.1) | 0.88 |
| Black, (%) | 477 (32.1) | 428 (32.6) | 44 (30.3) | 0.58 |
| Hispanic, (%) | 496 (33.3) | 410 (31.2) | 74 (51.0) | <0.0001 |
| White, (%) | 515 (34.6) | 476 (36.2) | 27 (18.6) | <0.0001 |
| Education, mean in years, (SD) | 10.9 (4.8) | 11.3 (4.6) | 7.3 (4.9) | <0.0001 |
| APOE ε4 allele %† | 310 (26.1) | 273 (25.6) | 31 (28.4) | 0.51 |
| Diabetes history (%) | 27.3 (5.5) | 213 (16.2) | 36 (24.8) | 0.01 |
| Stroke history (%) | 94.8 (12.6) | 103 (7.8) | 19 (13.0) | 0.03 |
| Hypertension history % | 0.88 (0.07) | 792 (60.3) | 99 (68.3) | 0.06 |
| Mean Non-HDL cholesterol (mg/dl) (SD)‡ | 253 (17.0) | 151.9 (36.9) | 140.2 (36.7) | 0.002 |
| Mean HDL cholesterol level (mg/dl) (SD)‡ | 124 (8.3) | 48.6 (14.6) | 45.7 (13.5) | 0.05 |
| History of heart disease, (%) | 901 (61.0) | 348 (26.5) | 43 (29.7) | 0.41 |
| Current smoking, (%) | 150.9 (37.1) | 131 (9.9) | 13 (8.9) | 0.70 |
| Body mass index* | 27.3 (5.5) | 27.4 (5.5) | 26.5 (5.9) | 0.06 |
| Waist circumference** | 94.8 (12.6) | 94.8 (12.4) | 95.1 (14.1) | 0.77 |
| Waist to hip ratio*** | 0.9 (0.07) | 0.8 (0.07) | 0.9 (0.07) | 0.002 |
*
Available in 1431 persons;
**
Available in 1437 persons;
***
Available in 1406 persons;
†
Available in 1177 persons;
‡
Available in 1118 persons
HDL = high density lipoprotein