TABLE 2.
Hazard ratios (HR) and 95% confidence intervals (CI) relating adiposity and late onset Alzheimer’s disease (LOAD). Model 1 is adjusted for gender and age; Model 2 is also adjusted for ethnicity, education, and APOE ε4 allele; Model 3 is additionally adjusted for type 2 diabetes, hypertension, heart disease, non-HDL cholesterol, HDL cholesterol, and stroke.
| At risk | LOAD cases | Model 1 | Model 2 | Model 3 | |
|---|---|---|---|---|---|
| Body Mass Index Quartiles | |||||
| 1 | 359 | 49 | 1.0 | 1.0 | 1.0 |
| 2 | 358 | 27 | 0.7 (0.5, 1.2) | 0.4 (0.3, 0.8) | 0.4 (0.2, 0.7) |
| 3 | 357 | 31 | 1.0 (0.6, 1.6) | 0.6 (0.4, 1.1) | 0.7 (0.4, 1.2) |
| 4 | 357 | 33 | 1.3 (0.8, 2.1) | 0.7 (0.4, 1.2) | 0.6 (0.3, 1.1) |
| P for trend | NA | 0.12 | 0.40 | 0.19 | |
| Waist Circumference Quartiles | |||||
| 1 | 389 | 44 | 1.0 | 1.0 | 1.0 |
| 2 | 393 | 34 | 0.9 (0.6, 1.4) | 0.5 (0.3, 0.9) | 0.4 (0.2, 0.7) |
| 3 | 344 | 32 | 1.2 (0.8, 2.0) | 0.8 (0.5, 1.4) | 0.7 (0.4, 1.3) |
| 4 | 330 | 35 | 1.6 (1.0, 2.6) | 0.9 (0.5, 1.6) | 0.8 (0.4, 1.4) |
| P for trend | NA | 0.01 | 0.89 | 0.61 | |
| Waist to Hip Ratio Quartiles | |||||
| 1 | 342 | 29 | 1.0 | 1.0 | 1.0 |
| 2 | 360 | 29 | 0.8 (0.5, 1.4) | 0.6 (0.4, 1.1) | 0.8 (0.5, 1.6) |
| 3 | 354 | 28 | 1.0 (0.6, 1.7) | 1.0 (0.6, 1.8) | 1.0 (0.5, 1.9) |
| 4 | 350 | 55 | 2.6 (1.7, 4.1) | 2.2 (1.3, 3.8) | 2.5 (1.3, 4.7) |
| P for trend | NA | <0.0001 | 0.0011 | 0.0019 | |