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Oxidative protein folding catalyzed by QSOX and PDI and the domain structure of a metazoan QSOX. Panel A shows the segregation of roles between QSOX and reduced PDI. Panel B depicts the domain structure and flow of reducing equivalents in a metazoan QSOX. Reducing equivalents are transferred from the unfolded protein substrate to the CIxxCII motif in the Trx domain (1), to the CIIIxxCIV motif in the Erv domain (2), to flavin (3), and finally to molecular oxygen (4).
