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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Alcohol. 2012 Mar 22;46(4):377–387. doi: 10.1016/j.alcohol.2011.10.003

Figure 3. Narp deletion promotes a conditioned place-aversion and reduces motor hyperactivity during withdrawal.

Figure 3

When assayed in a place-conditioning paradigm (8 pairings of 3 g/kg alcohol, IP), KO mice exhibited a conditioned place-aversion when tested in an alcohol-free state, while WT mice exhibited a significant place-preference (A). When the locomotor activity exhibited by WT and KO mice under alcohol-free conditions was compared between the 15-min pre- and post-conditioning tests, KO mice exhibited very little change in locomotor activity, while WT mice exhibited elevated locomotion on the post-test (B). Conversely, WT mice spent significantly less time being immobile (no movement detected for 15 sec) on the post-versus pre-conditioning test, while an increase in immobility was observed in KO animals (C). Data present the mean ± SEM of the number of animals indicated in parentheses. +p<0.05 vs. WT.