Table 1.
Variable |
WT | KO |
---|---|---|
Day 1 Alcohol Dose-Intake Function (g/kg) | ||
0% | 131.8 ± 28.1 | 99.4 ± 33.0 |
3% | 1.57 ± 0.3 | 0.42 ± 0.4 |
6% | 5.0 ± 1.4 | 4.9 ± 1.6 |
12% | 7.1 ±1.7 | 8.6 ± 2.0 |
Day 1 Alcohol Preference-Intake Function (% total fluid intake) |
||
0% | 42.6 ± 5.1% | 33.9 ± 5.7% |
3% | 15.4 ± 2.3% | 5.2 ± 2.7% |
6% | 24.2 ± 6.9% | 32.8 ± 8.1% |
12% | 17.8 ± 4.8% | 28.1 ± 5.6% |
Mean Alcohol Preference-Intake Function Across Drinking Days (% total fluid intake) |
||
0% | 32.9 ± 8.4% | 39.9 ± 9.8% |
3% | 17.7 ± 1.8% | 5.4 ± 2.1% |
6% | 26.1 ± 6.5% | 30.94 ± 7.6% |
12% | 23.6 ± 4.1% | 23.7 ± 4.8% |
Spontaneous Motor Behavior | ||
Novel Environment: Distance (m) | 19.2 ± 2.0 | 17.3 ± 2.0 |
Novel Environment: Immobility (sec) | 17.2 ± 2.7 | 15.1 ± 5.8 |
PreTest: Distance (m) | 16.5 ± 1.7 | 11.8 ± 2.4 |
PreTest: Immobility (sec) | 296.4 ± 39.5 | 348.9 ± 78.1 |
Saline Injection 1: Distance (m) | 8.1 ± 1.1 | 6.1 ± 1.2 |
Δ Locomotion across saline inj’s (m) | −3.1 ± 1.7 | −4.0 ± 1.0 |
Alcohol-induced Motor Behavior Injection 1: Distance (m) | 3.5 ± 1.3 | 5.6 ± 1.3 |
Injection 1: Immobility (sec) | 787.8 ± 41.0 | 679.6 ± 63.05 |
Δ Locomotion across alcohol inj’s (m) | 9.0 ± 2.7 | 7.9 ± 3.9 |
Δ Immobility across alcohol inj’s (sec) | −291.5 ± 94.7 | −269.7 ± 118.3 |