. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: Heart Rhythm. 2012 Jan 28;9(6):892–898. doi: 10.1016/j.hrthm.2012.01.020

Table 3.

Multivariate analysis: Risk factors for ACA/SCD among patients with LQT1 by sex^*^†

	Men with LQT1		Women with LQT1
	HR (95% CI)	P	HR (95% CI)	P
Mutation location (vs nonmissense mutations)
Cytoplasmic loop (S2–S3/S4–S5 linkers)	1.21 (0.72–2.04	0.48	2.62 (1.59–4.26)	<.001
MS	1.02 (0.63–1.97)	0.54	1.01 (0.62–1.89)	.56
N/C terminus	0.89 (0.52–1.91)	0.87	1.14 (0.51–2.37)	.43
QTc duration (ms)
500–550 vs <500	1.70 (0.63–4.57)	0.29	6.85 (2.74–17.10)	<.001
>550 vs < 500	3.11 (1.19–8.15)	0.02	5.93 (1.89–18.62)	.002
Time-dependent syncope
Syncope vs no syncope	4.06 (2.22–7.41)	<0.001	2.43 (1.43–4.85)	.002

ACA = aborted cardiac arrest; CI = confidence interval; HR = hazard ratio; LQT1 = long QT syndrome type 1; QTc = corrected QT interval; SCD = sudden cardiac death; MS = membrane spanning.

Findings were further adjusted for missing QTc values, time-dependent beta-blocker therapy.

^†

Models were carried out in the total population by using interaction-term analysis, with interactions tested one at a time; cytoplasmic loop-by-sex interaction = .07; all other interaction P values were >.10.