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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Biomaterials. 2012 May 9;33(22):5514–5523. doi: 10.1016/j.biomaterials.2012.04.001

Figure 4. Metabolic remodeling by T3 promotes mesenchymal-to-epithelial transition.

Figure 4

A. Q-PCR quantitation of two epithelial markers, E-cadherin and CLDN3. Addition of T3 receptor antagonist TRA reduces the activation of E-cadherin and CLDN3 by T3 treatment. 293 cells were used as the positive control.

B–C. Down-regulation of Snail1 and Snail2, two mediators of the epithelial-to-mesenchymal transition.

D. Morphological changes of the reprogrammed cells in the presence or absence of T3.

E. Immunostaining of E-cadherin expression in reprogrammed cells in the presence or absence of T3. Note that the T3 receptor antagonist TRA abolishes the T3-mediated activation of E-cadherin.