Figure 7. The A2AAR antagonist SCH58261 protects against EAE mediated by adoptively transferred A2AAR−/− cells.
EAE was induced in T cell deficient Tcrα−/− mice that received adoptively transferred lymphocytes from wild type (squares) or A2AAR−/− (circles) mice and given SCH58261 A2AAR antagonist (open shape) or vehicle (closed shape) treatment (n ≤ 5). Disease activity was monitored daily and the mean EAE score was calculated.