Table 1.
Prevalence of AID among women with TS compared to women with POI and US female population
| Diagnosis | TS (n=224) | POI (n=457) | P (TS v POI) | US female population* | RR in TS (95%CI) |
|---|---|---|---|---|---|
| Prevalence % (N) | Prevalence % | ||||
| Hashimoto’s thyroiditis | 36.6 %(82) | 15.1% (69) | < 0.0001 | 5.8%25 | 7.2 (5.85–8.7) |
| IBD^ | 4.0% (9) | 0.2%(1) | <0.0001 | 0.46%38 | 17.2 (8.5–33.2) |
| Celiac Disease | 2.7% (6) | 0 | 0.002 | 0.063%39† | 42.5 (12.4–144.8) |
| Graves disease | 2.7% (6) | 0.9% (4) | 0.354 | 1.9%9 | 1.4 (0.57–3.22) |
| Type-1 DM | 0.9% (2) | 0.7% (3) | 0.552 | 0.3840 | 2.37 (0.40–9.9) |
| Psoriasis | 3.1% (7) | 1.3%(6) | 0.114 | 3.15%41 | 0.99 (0.3–3.1) |
| Rheumatoid arthritis | 0.9% (2) | 1.5% (7) | 0.642 | 1.06%42 | 0.84 (0.14–3.40) |
| Lupus | 0.9% (2) | 0.2% (1) | 0.34%43 | 2.6 (0.44–11.0) | |
| Vitiligo | 0.4% (1) | 0.4% (2) | 0.4%9 | ||
| Ankylosing spondylitis | 0.4% (1) | 0 | 0.07%42 | ||
| Iridocyclitis | 0.4% (1) | 0 | 0.06%44 | ||
| Alopecia totalis | 0.4% (1) | 0 | 0.024%45 | ||
| Myasthenia gravis | 0.4% (1) | 0 | 0.0074%46 | ||
| Sarcoidosis | 0.4% (1) | 0 | 0.005%47 | ||
| Rheumatic fever | 0 | 0.4% (2) | <0.3%48 | ||
| Addison’s disease | 0 | 0.2% (1) | 0.026%46 | ||
| Pemphigoid | 0 | 0.2% (1) | 0.008%49 | ||
| Dermatomyositis | 0 | 0.2% (1) | 0.0068%9 | ||
| Behcet syndrome | 0 | 0.2% (1) | 0.0064%50 | ||
| AI Oophoritis | 0 | 0.2% (1) | No data | ||
The prevalence data for the U.S. adult female population, obtained from the sources cited in the Table “column 5” includes all women age ≥20 and thus many older women relative to the TS and POI groups.
IBD = Inflammatory Bowel Disease: Crohn’s disease n=5 women with TS and 1 wit POI and Ulcerative colitis, n=4 women with TS).
Diagnosis of celiac disease was based on clinical grounds.
Statistical comparison of prevalence of a specific AID between TS and POI groups was performed only if there were ≥ 5 cases by using a generalized linear model with correction for age; the Bonferroni correction for multiple comparisons specifies P<0.007 as significant. The risk of a specific autoimmune disease relative to the US adult female population (RR) was calculated only for TS group, and only for diagnoses with ≥2 cases in the TS group.