Table 3.
Metabolites and adduct | Metabolite | A549 | H358 | HBEC-KT |
---|---|---|---|---|
GSH-B[a]P-7,8-dione | M1 | 0.7 % | 0.8 % | — |
O-mono-sulfate-catechol | M2 | 12.2 % | 14.9 % | 3.5 % |
O-mono-glucuronide-catechol | M3 | 4.3 % | — | — |
NAC-B[a]P-7,8-dione | M4 | 1.4 % | 2.4 % | 11.1 % |
Unknown metabolite with m/z 444 | M5 | 16.2 % | 25.3 % | 6.4 % |
adenine-B[a]P-7,8-dione | M6 | 30.1 % | 25.7 % | 48.4 % |
B[a]P-7,8-dione | — | 5.7 % | 4.2 % | 2.1 % |
Mono-hydroxylated-B[a]P-7,8-dione | M7 | 7.8 % | 1.7 % | 10.1 % |
O-methylated-catechol | M8 | 6.6 % | 1.2 % | 5.8 % |
Other unknown metabolites | — | 15.0 % | 23.8 % | 12.6 % |