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Inhibition of PKMζ in rACC fails to block cocaine-induced CPP. (A) Scrambled ZIP into the rACC did not block cocaine (1 mg/kg, i.v.) induced CPP when given 24 hr prior to conditioning. Administration of ZIP into the rACC also did not block cocaine induced CPP when given 24 hr prior to conditioning. (B) Difference scores confirmed significant increase in time spent in the cocaine paired chamber irrespective of rACC ZIP treatment. Graphs represent mean ± SEM, *p<0.05, n=10-12.
