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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Pain. 2012 Apr 13;153(6):1232–1243. doi: 10.1016/j.pain.2012.02.035

Figure 3. Sensitivity to noxious heat stimuli and offset analgesia during remifentanil infusion (N=19).

Figure 3

Reductions in maximum VAS ratings to constant 49°C stimuli, 40 s (A, Peak VAS) and to 49-50-49°C stimuli (B, MaxT2) occurred at the Inf1 time point, but not at the Inf2 time point. Similarly, Min Offset values from 49-50-49°C stimuli were significantly reduced at the Inf1 time point (C). However, the difference between MaxT2 and Min Offset values was not significantly altered during infusion, resulting in no reductions in Magnitude Offset Analgesia (D). No significant temporal alterations in offset analgesia were observed during remifentanil infusion (E, Min Offset Latency) and after sensations did not occur (F, VAS End Latency). Mean ± SEM; VAS, visual analogue scale.