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Developmental differences in plasma nicotine and cotinine following acute or chronic nicotine administration. A: Plasma cotinine was significantly higher in pre-adolescent mice that received 0.09 mg/kg nicotine relative to adolescents and adults. B: Plasma cotinine levels differed between pre-adolescent and adult mice treated with 6.3 mg/kg/d chronic nicotine. Error bars indicate SEM, (*) indicates p < 0.05.
