Fig. 1.

Oxidative DNA base modifications evoked by a mixture of methacrylates containing 45% 2-hydroxyethyl methacrylate and 55% bisphenol A-diglycidyl dimethacrylate (w/w) (HEMA/Bis-GMA) during a 6 h exposure at 37°C without (empty symbols) or with (filled symbols) a subsequent 15-min incubation with human 8-hydroxyguanine 1 (hOGG1) at 1 μM. The base modifications were measured as percentage of DNA in the tail in the alkaline comet assay. The concentration of the mixture is expressed as the Bis-GMA concentration. The number of cells analyzed for each sample was 100. The results are the mean of three independent experiments. Error bars denote SEM, **p < 0.01, ***p < 0.001 as compared with the unexposed to the mixture controls