Table 3.
Anthropometrical parameters, liver metabolism parameters and inflammatory markers in mHD group (mHD1—at the beginning of the study, mHD2—after 1 year of the study) and in healthy volunteers (HV) as controls
| Parameter | mHD |
P value mHD1 vs. mHD2 |
HV as controls | |
|---|---|---|---|---|
| mHD1 | mHD2 | |||
| WHR | 0.95 ± 0.22 | 0.94 ± 0.12 | 0.86 | 0.97 ± 0.05 |
| BMI (kg/m2) | 25.16 ± 4.69 | 24.56 ± 4.75 | 0.07 | 25.6 ± 4.3 |
| Cholesterol (mg/dl) | 178.9 ± 47.4 | 173 ± 36.6 | 0.49 | 170.8 ± 24.3 |
| Triglycerides (mg/dl) | 179 ± 22.6** | 175.7 ± 23.2** | 0.54 | 92.3 ± 26.5 |
| Albumin (g/l) | 38.091 ± 5.34** | 36.73 ± 4.12** | 0.19 | 44.7 ± 1.71 |
| Bilirubin (mg/dl) | 0.6 ± 0.22 | 0.6 ± 0.13 | 0.91 | 0.6 ± 0.1 |
| ALT (IU/l) | 15.34 ± 7.8 | 15.38 ± 6.2 | 0.83 | 15.57 ± 7.4 |
| AST (IU/l) | 16.39 ± 5.7 | 16.44 ± 7.42 | 0.87 | 16.57 ± 6.31 |
| hsCRP (mg/l) | 7.42 ± 3.56** | 13.29 ± 12.03*** | 0.00018 | 2.3 ± 0.6 |
| IL-1 (pg/ml) | 3.98 ± 0.67*** | 8.41 ± 1.88*** | 0.00000 | 0.6 ± 0.01 |
| IL-6 (pg/ml) | 36.82 ± 39.84*** | 48.01 ± 109.72*** | 0.5 | 4.3 ± 0.7 |
| TNF-alpha (pg/ml) | 28.74 ± 70.7*** | 25.57 ± 21.10*** | 0.79 | 1.2 ± 0.1 |
The differences between mHD1 and mHD2 were estimated by paired t test. To compare mHD1 and mHD2 with HV as controls, unpaired the Student’s t test for normally distributed variables and the Mann–Whitney rank sum test for the variables with non-normal distribution were used
Data were given are means ± SD
WHR waist-to-hip ratio, BMI body mass index calculated as follows: BMI = weight (kg)/[height (m)]2, ALT alanine aminotransferase, AST aspartate aminotransferase, hsCRP high sensitivity C-reactive protein, IL-1 interleukin 1, IL-6 interleukin 6, TNF-alpha tumour necrosis factor-alpha
Significant differences when P < 0.05
** P < 0.01; *** P < 0.001 versus HV