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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Neurobiol Dis. 2012 Mar 26;47(1):92–101. doi: 10.1016/j.nbd.2012.03.026

Figure 4. Spikes become repetitive.

Figure 4

(A) An EEG sample is shown from a rat that initially developed isolated spikes. By the second week, ‘doublets’ were seen, and by the third week, spikes (indicated by *) occurred repetitively with 3–6 in a row. (B) Quantifying this increase by calculating the percent of spikes that were clustered with other spikes shows a progressive increase in clustering with time (n=11; R2=0.492; Linear regression slope=0.75%/day, p=0.0025).