Figure 7. Interictal spikes alter rat motility behavior.
(A) Open field activity measurements show that tetanus-treated spiking rats are consistently hyperactive relative to sham-operated controls and diverged significantly by the third week of observation (n=4 tetanus, 4 sham; 1 week: p=0.054, 8068.1±1139.0cm versus 5568.7±565.5cm; 2 weeks: p=0.098, 8146.0±1832.1cm versus 5501.3±1078.1cm; 3 weeks: p=7.68x10−5, 8641.7±338.2cm versus 4680.2±236.7cm). (B) Similarly, spiking animals also showed an increase in the number of discrete ambulatory episodes per recording session by the third week (1 week: p=0.116, 296.1±54.7 versus 215.6±42. episodes; 2 weeks: p=0.223, 277.4±49.4 versus 219.9±50.8 episodes; 3 weeks: p=0.00110, 307.0±21.3 versus 169.1±18.3 episodes). (C) The two groups did not differ in the speed of ambulation, however (1 week: p=0.824, 18.7±0.9 versus 18.4±1.3 cm/s; 2 weeks: p=0.613, 18.4±0.6 versus 18.7±0.6 cm/s; 3 weeks: p=0.402, 19.3±0.6 versus 18.7±0.8 cm/s).