FIGURE 1.

Domain 1 of eRF1 mediates stop codon recognition. (A) Protein sequence alignment of eRF1 domain one from multiple species. The star symbol indicates fully conserved residues; the colon indicates strong conservation; and the period indicates weak conservation. (B) Location of eRF1 residues in the context of the human eRF1 structure (Song et al. 2000). YCF and TASNIKS residues are in black type and bordered by dotted lines. Residues between the TASNIKS and YCF motifs are in white type. The three solid white circles indicate the cavities proposed to mediate stop codon recognition (Bertram et al. 2000).