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. 2011 Dec 3;67(6):477–487. doi: 10.1136/thoraxjnl-2011-200508

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© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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(A) Blocking the interaction between urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) attenuates the rate of wound repair (n=4). (B) Soluble uPAR (suPAR), (C) uPA and (D) plasminogen activator inhibitor 1 (PAI-1) levels decrease in supernatants at 24 h in the presence of blocking antibody. (E) Zymography and (F) an ELISA-based assay detect matrix metalloproteinase (MMP)-2 and MMP-9 activity at 24 h. *p<0.05, **p<0.01, ***p<0.001.