Figure 4.

Chronic adolescent corticosterone (CORT) treatment enhances sensitivity to yohimbine-induced impulsivity on the 5-choice serial reaction time task (5CSRTT). Adolescent CORT-treated and control rats were given injections of saline and varying doses of yohimbine prior to testing on the 5CSRTT with a stable intertrial interval (ITI) and stimulus duration. Adolescent CORT-treated rats had an upward and leftward shift in the yohimbine dose–response curve, indicative of a greater sensitivity to yohimbine's effects on impulsivity (a), whereas the number of omissions on the task was not different between groups and was not significantly disrupted except at the highest dose of yohimbine (b). ^**p<0.01.