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. 2012 Feb 1;37(7):1588–1599. doi: 10.1038/npp.2012.3

Figure 5.

Figure 5

Stress exposure and injection of an NPS receptor antagonist into the LA: effects on conditioned fear. NS: non-stressed animals, injection of SHA68 (SHA68_NS), or vehicle (cremophore, Vehicle_NS) bilaterally into the LA 10 days before fear conditioning. IS-10 D: exposure to IS 10 days before fear conditioning, with injection of SHA68 (SHA68_IS-10D) or vehicle (cremophore, Vehicle_IS-10D) 20 min before IS. (a, b) Fear acquisition. Freezing to the context during a period of 2 min before the first CS+ presentation for session 1 and 2 (a), and freezing to the CS− (b). The data represent the mean of freezing for 6-block CS- and 3-block CS+. (c, d) Conditioned fear responses. (c) CS+-evoked and (d) freezing evoked by CS− during fear memory retrieval (R1 session), extinction training (R1–R6), and extinction recall (ER). Substance effect (two-way ANOVA with repeated measures for extinction training (R1–R6) in stressed animals): ***p<0.001; substance effect for ER session, t-test: $p<0.05. Stress effect in SHA68-(***p<0.001) and vehicle-injected (*p<0.05) animals.