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. 2012 Jun;23(6):1008–1018. doi: 10.1681/ASN.2011070738

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Copyright © 2012 by the American Society of Nephrology

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Figure 6. — Transcription factors putatively binding to cis-elements in the 5′-flanking regions of Aqp2, Aqp3, Scnn1b, and Scnn1g. Putative transcription factor binding elements (TFBSs) within 1000 bp upstream of the transcriptional start sites of (A) Aqp2, (B) Aqp3, (C) Scnn1b, and (D) Scnn1g analyzed using the Genomatix database and software suite. All shown TFBSs are conserved among human, dog, rat, and mouse. Transcription factors identified in this study that potentially bind to these TFBSs are indicated. Numbers represent center of motif in mouse. Transcription factors significantly changed above threshold are given in red (increase) or green (decrease). Genomatix TFBS family names are as follows: V$ABDB, abdominal B-type homeodomain transcription factors; V$AP1F, AP1 activating protein 1; V$AP1R, MAF and AP1 related factors; V$AP2F, activator protein 2; V$CAAT, CCAAT box binding proteins; V$CP2F, CP2-erythrocyte factor related to Drosophila Elf1; V$CREB, cAMP-responsive element-binding proteins; V$CTCF, CTCF and BORIS gene family transcriptional regulators; V$E2FF, E2F-myc activator/cell cycle regulator; V$EBOX, E-box binding factors; V$EGRF, EGR/nerve growth factor induced protein C and related factors; V$EREF, estrogen response elements; V$ETSF, human and murine ETS1 factors; V$FKHD, Fork head domain factors; V$GATA, GATA binding factors; V$HAML, human acute myelogenous leukemia factors; V$HESF, vertebrate homologs of enhancer of split complex; V$HNF1, hepatic NF 1; V$HOXF, paralog hox genes 1–8 from the four hox clusters A, B, C, D; V$IRFF, IFN regulatory factors; V$KLFS, Kruppel-like transcription factors; V$LEFF, LEF1/TCF; V$MAZF, Myc-associated zinc fingers; V$NFAT, NF of activated T cells; V$NFKB, NFκB/c-rel; V$NR2F, nuclear receptor subfamily 2 factors; V$OCT1, octamer binding protein; V$P53F, p53 tumor suppressor–negative regulator of the tumor suppressor Rb; V$PBXC, PBX1 - MEIS1 complexes; V$PTF1, pancreas transcription factor 1, heterotrimeric transcription factor; V$PURA, Pur-α binds both single-stranded and double-stranded DNA in a sequence-specific manner; V$RREB, Ras-responsive element-binding protein; V$RXRF, RXR heterodimer binding sites; V$SMAD, vertebrate SMAD family of transcription factors; V$SORY, SOx/sRY-sex/testis determining and related HMG box factors; V$SP1F, GC-Box factors SP1/GC; V$STAF, selenocysteine tRNA activating factor; V$STAT, signal transducer and activator of transcription; V$XBBF, X-box binding factors; V$YY1F, activator/repressor binding to transcription initiation site; V$ZBPF, zinc binding protein factors.